G. Lehto, Sonya: search on Z-Library

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1

Fused Piperidines as a Novel Class of Potent and Orally Available Transient Receptor Potential Melastatin Type 8 (TRPM8) Antagonists

Tamayo, Nuria A., Bo, Yunxin, Gore, Vijay, Ma, Vu, Nishimura, Nobuko, Tang, Phi, Deng, Hong, Klionsky, Lana, Lehto, Sonya G., Wang, Weiya

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.86 MB

english, 2012

2

Discovery of TRPM8 Antagonist (S)-6-(((3-fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic acid (AMG 333), a Clinical Candidate for the Treatment of Migraine

Horne, Daniel B., Biswas, Kaustav, Brown, James, Bartberger, Michael D., Clarine, Jeffrey, Davis, Carl D, Gore, Vijay K, Harried, Scott, Horner, Michelle, Kaller, Matthew R., Lehto, Sonya G., Liu, Qin

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.18 MB

english, 2018

3

Optimization of Potency and Pharmacokinetic Properties of Tetrahydroisoquinoline Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists

Horne, Daniel B., Tamayo, Nuria A., Bartberger, Michael D., Bo, Yunxin, Clarine, Jeffrey, Davis, Carl D., Gore, Vijay K., Kaller, Matthew R., Lehto, Sonya G., Ma, Vu V., Nishimura, Nobuko, Nguyen, Tho

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 761 KB

english, 2014

4

The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors

Bregman, Howard, Simard, Jeffrey R., Andrews, Kristin L., Ayube, Shawn, Chen, Hao, Gunaydin, Hakan, Guzman-Perez, Angel, Hu, Jiali, Huang, Liyue, Huang, Xin, Krolikowski, Paul H., Lehto, Sonya G., Lew

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 4.21 MB

english, 2017

5

Voltage-gated sodium channel function and expression in injured and uninjured rat dorsal root ganglia neurons

Yin, Ruoyuan, Liu, Dong, Chhoa, Mark, Li, Chi-Ming, Luo, Yi, Zhang, Maosheng, Lehto, Sonya G., Immke, David C., Moyer, Bryan D.

Journal:

International Journal of Neuroscience

Year:

2015

Language:

english

File:

PDF, 707 KB

english, 2015

6

Chromenones as potent bradykinin B1 antagonists

Marian C. Bryan, Kaustav Biswas, Tanya A.N. Peterkin, Robert M. Rzasa, Leyla Arik, Sonya G. Lehto, Hong Sun, Feng-Yin Hsieh, Cen Xu, Robert T. Fremeau, Jennifer R. Allen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 350 KB

english, 2012

7

AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia

Lehto, Sonya G., Weyer, Andy D., Zhang, Maosheng, Youngblood, Beth D., Wang, Judy, Wang, Weiya, Kerstein, Patrick C., Davis, Carl, Wild, Kenneth D., Stucky, Cheryl L., Gavva, Narender R.

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2015

Language:

english

File:

PDF, 494 KB

english, 2015

8

Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain

BaoXi Gao, Markus Hierl, Kristie Clarkin, Todd Juan, Hung Nguyen, Marissa van der Valk, Hong Deng, Wenhong Guo, Sonya G. Lehto, David Matson, Jeff S. McDermott, Johannes Knop, Kevin Gaida, Lei Cao, Da

Journal:

Year:

2010

Language:

english

File:

PDF, 1.07 MB

english, 2010

9

Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels

G.R. Dubé, Sonya G. Lehto, Nicole M. Breese, Scott J. Baker, Xueqing Wang, Mark A. Matulenko, Prisca Honoré, Andrew O. Stewart, Robert B. Moreland, Jorge D. Brioni

Journal:

Year:

2005

Language:

english

File:

PDF, 247 KB

english, 2005

10

Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel Na V 1.7

Kornecook, Thomas J, Yin, Ruoyuan, Altmann, Stephen, Be, Xuhai, Berry, Virginia, Ilch, Christopher P, Jarosh, Michael, Johnson, Danielle, Lee, Josie H, Lehto, Sonya G, Ligutti, Joseph, Liu, Dong, Luth

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2017

Language:

english

File:

PDF, 1.21 MB

english, 2017

11

PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache?

Hoffmann, Jan, Miller, Silke, Martins-Oliveira, Margarida, Akerman, Simon, Supronsinchai, Weera, Sun, Hong, Shi, Licheng, Wang, Judy, Zhu, Dawn, Lehto, Sonya, Liu, Hantao, Yin, Ruoyuan, Moyer, Bryan D

Journal:

Year:

2020

File:

PDF, 851 KB

2020

12

Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation

Narender R Gavva, Carl Davis, Sonya G Lehto, Sara Rao, Weiya Wang…

Journal:

Year:

2012

Language:

english

File:

PDF, 375 KB

english, 2012

13

Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats

Chang Z. Zhu, Scott Baker, Odile EI-Kouhen, Sonya G. Lehto, Peter R. Hollingsworth, Donna M. Gauvin, Gricelda Hernandez, GuoZhu Zheng, Renjie Chang, Robert B. Moreland, Andrew O. Stewart, Jorge D. Bri

Journal:

European Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 284 KB

english, 2008

14

A Review of Current Animal Models of Osteoarthritis Pain

N. D'Souza, Warren, Y. Ng, Gordon, D. Youngblood, Bradley, Tsuji, Wayne, G. Lehto, Sonya

Journal:

Current Pharmaceutical Biotechnology

Year:

2011

Language:

english

File:

PDF, 188 KB

english, 2011

15

Discovery of Potent, Orally Bioavailable Phthalazinone Bradykinin B1 Receptor Antagonists

Biswas, Kaustav, Peterkin, Tanya A. N., Bryan, Marian C., Arik, Leyla, Lehto, Sonya G., Sun, Hong, Hsieh, Feng-Yin, Xu, Cen, Fremeau, Robert T., Allen, Jennifer R.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.40 MB

english, 2011

16

Correlation between brain/plasma ratios and efficacy in neuropathic pain models of selective metabotropic glutamate receptor 1 antagonists

Guo Zhu Zheng, Pramila Bhatia, Teodozyj Kolasa, Meena Patel, Odile F. El Kouhen, Renjie Chang, Marie E. Uchic, Loan Miller, Scott Baker, Sonya G. Lehto, Prisca Honore, Jill M. Wetter, Kennan C. Marsh,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 137 KB

english, 2006

17

Central Pituitary Adenylate Cyclase 1 Receptors Modulate Nociceptive Behaviors in Both Inflammatory and Neuropathic Pain States

Rachel Davis-Taber, Scott Baker, Sonya G. Lehto, Chengmin Zhong, Carol S. Surowy, Connie R. Faltynek, Victoria E. Scott, Prisca Honore

Journal:

The Journal of Pain

Year:

2008

Language:

english

File:

PDF, 248 KB

english, 2008

18

Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse

Amanda D. Green, Katrina K. Young, Sonya G. Lehto, Shad B. Smith, Jeffrey S. Mogil

Journal:

Year:

2006

Language:

english

File:

PDF, 202 KB

english, 2006

19

Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine

Weyer, Andy, Lehto, Sonya

Journal:

Pharmaceuticals

Year:

2017

Language:

english

File:

PDF, 212 KB

english, 2017

20

Corrigendum to “Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels” [Pain 117 (2005) 88–96]

G.R. Dubé, Sonya G. Lehto, Nicole M. Breese, Scott J. Baker, Xueqing Wang, Mark A. Matulenko, Prisca Honoré, Andrew O. Stewart, Robert B. Moreland, Jorge D. Brioni

Journal:

Year:

2005

Language:

english

File:

PDF, 70 KB

english, 2005

21

TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: compounds’ pharmacological profiles, in-vivo targets, thermoeffectors recruited, and implications for drug development

Garami, Andras, Pakai, Eszter, McDonald, Heath A., Reilly, Regina M., Gomtsyan, Arthur, Corrigan, Joshua J., Pinter, Erika, Zhu, Dawn X. D., Lehto, Sonya G., Gavva, Narender R., Kym, Philip R., Romano

Journal:

Acta Physiologica

Year:

2018

Language:

english

File:

PDF, 1.16 MB

english, 2018

22

Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

Huang, Xin, Shaffer, Paul L, Ayube, Shawn, Bregman, Howard, Chen, Hao, Lehto, Sonya G, Luther, Jason A, Matson, David J, McDonough, Stefan I, Michelsen, Klaus, Plant, Matthew H, Schneider, Stephen, Si

Journal:

Nature Structural and Molecular Biology

Year:

2016

Language:

english

File:

PDF, 1.39 MB

english, 2016

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